The screening and ranking algorithm to detect DNA copy number variations
نویسندگان
چکیده
منابع مشابه
The Screening and Ranking Algorithm to Detect Dna Copy Number Variations.
DNA Copy number variation (CNV) has recently gained considerable interest as a source of genetic variation that likely influences phenotypic differences. Many statistical and computational methods have been proposed and applied to detect CNVs based on data that generated by genome analysis platforms. However, most algorithms are computationally intensive with complexity at least O(n2), where n ...
متن کاملModified screening and ranking algorithm for copy number variation detection
MOTIVATION Copy number variation (CNV) is a type of structural variation, usually defined as genomic segments that are 1 kb or larger, which present variable copy numbers when compared with a reference genome. The screening and ranking algorithm (SaRa) was recently proposed as an efficient approach for multiple change-points detection, which can be applied to CNV detection. However, some practi...
متن کاملwuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
Copy number variants (CNVs) are currently defined as genomic sequences that are polymorphic in copy number and range in length from 1000 to several million base pairs. Among current array-based CNV detection platforms, long-oligonucleotide arrays promise the highest resolution. However, the performance of currently available analytical tools suffers when applied to these data because of the low...
متن کاملGenome analysis Modified screening and ranking algorithm for copy number variation detection
Motivation: Copy number variation (CNV) is a type of structural variation, usually defined as genomic segments that are 1 kb or larger, which present variable copy numbers when compared with a reference genome. The screening and ranking algorithm (SaRa) was recently proposed as an efficient approach for multiple change-points detection, which can be applied to CNV detection. However, some pract...
متن کاملMethods to detect and analyze copy number variations at the genome-wide and locus-specific levels.
Copy number variations (CNVs) have effects on phenotypes by altering transcription levels of genes and may have major impacts on protein sequence, structure and function. Therefore, CNV screening and analysis focused on the identification of CNV-genetic disease relations are actively progressing. CNVs can be detected and analyzed by various methodologies at the genome-wide and locus-specific le...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2012
ISSN: 1932-6157
DOI: 10.1214/12-aoas539